Chloramphenicol structural formula

Chloramphenicol structural formula

Structural formula

Business number 017V
Molecular formula C11H12Cl2N2O5
Molecular weight 323.14




Genetic engineering research reagents

Numbering system

CAS number:56-75-7

MDL number:MFCD00078159

EINECS number:200-287-4

RTECS number:AB6825000

BRN number:2225532

PubChem number:24892250

Physical property data

1. Character: white or slightly yellow Green needle-like crystals.

2. Density ( g/mL,25/4℃) : 1.474

3. Relative vapor density (g/mL,AIR=1): Undetermined

4. Melting point ( ºC): 150.5-151.5(149.7-150.7). Can sublimate under high vacuum.

5. Boiling point ( ºC,Normal pressure): Undetermined

6. Boiling point ( ºC,5.2kPa): Undetermined

7. Refractive Index: Undetermined

8. Flashpoint (ºC): Undetermined

9. Specific optical rotation (º): 19.5° (c=6, EtOH) .

10. Autoignition point or ignition temperature (ºC): Not OK

11. Vapor pressure (kPa,25ºC): Undetermined

12. Saturation vapor pressure (kPa,60ºC): Undetermined

13. heat of combustion (KJ/mol): Undetermined

14. Critical temperature (ºC): Undetermined

15. Critical Pressure (KPa): Undetermined

16. Oil and water (octanol/Water) partition coefficient pair Value: Undetermined

17. Explosion limit (%,V/ V): Undetermined

18. Lower explosion limit (%,V/V): Not OK

19. Solubility: Slightly soluble in Water (2.5mg/ml, 25℃) , slightly soluble in propylene glycol (150.8mg/ml), easily soluble in methanol, ethanol, butanol, ethyl acetate, acetone, insoluble in ether, benzene, petroleum ether and vegetable oil.

Toxicological data


Ecological data


Molecular structure data

1, Molar refractive index:72.55

2. Molar volume (m3/mol):208.8

3. isotonic specific volume (90.2K):595.5

4. Surface Tension (dyne/cm):66.1

5. Polarizability10-24cm3): 28.76

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 5

4. Number of rotatable chemical bonds: 5

5. Number of tautomers: 2

6. Topological molecule polar surface area 115

7. Number of heavy atoms: 20

8. Surface charge: 0

9. Complexity: 342

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 2

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability


Storage method

This product should be stored in a sealed, cool place away from light.

Synthesis method

Countries around the world have conducted a large number of studies on the production methods of chloramphenicol, which can be summarized as follows: (1) Yes Nitroacetophenone method; (2 ) styrene method; (3) Cinnamyl alcohol method; (4) p-nitrocinnamic alcohol method; (5) p-Nitrobenzaldehyde method. my country adopts the p-nitroacetophenone method, which obtains chloramphenicol from ethylbenzene through nitration; oxidation; bromination; salt formation; hydrolysis; acetylation; addition; reduction; decomposition; separation; and dichloroacetylation. .


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